Trait Data and Analysis for 3634656

Cholinergic receptor, nicotinic, alpha 3 (neuronal)

Details and Links

Group Human: HSB group
Tissue Ventrolateral Prefrontal Cortex mRNA
Gene Symbol CHRNA3
Aliases Wikidata: BAIPRCK; LNCR2; NACHRA3; PAOD2; (a)3; A730007P14Rik; Acra-3; Acra3
GeneNetwork: CHRNA3; LNCR2; NACHRA3; PAOD2
Location Chr 15 @ 78.885394 Mb
Summary This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Database Human Ventrolateral Prefrontal Cortex Affy Hu-Exon 1.0 ST (Jul11) Quantile
Resource Links Gene    OMIM    GeneMANIA    Protein Atlas    Rat Genome DB    GTEx Portal   
BioGPS    STRING    PANTHER    Gemma    ABA    EBI GWAS   

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